関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 6-Nitro-3-phenylacetamidobenzoic acid | HCID 193864 | — |
| 反応物 | Penicillin V Potassium | HCID 23676814 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 6-Aminopenicillanic acid | HCID 11082 | 86.1% |
反応手順
290 g of carrier-bound penicillinacylase according to Example 4, having an enzymatic activity of 2,803 U (NIPAB test) and 138 g of potassium penicillin V are added to 2,000 ml of water and stirred for 9 hours at 38°C. The pH value is kept constant at 7.8 by continuous addition of triethylamine. The mixture is worked up as described in Example 1. Yields of 6-APA 64.3 g (86.1% of theory); purity 97.4%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US03941756 |
|---|
| 出典データセット | uspto-grants-1976_03 |
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| ORD ID | ord-b637f9b0888d47a1a842be6a33c686f8 |
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| 出典メモ | uspto-grants-1976_03 |
|---|
