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Sodium Hydroxide → N-Acetyl-L-phenylalanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N-Acetyl-L-phenylalanine | HCID 74839 | — |
| 反応物 | Methyl 3-phenyl-DL-alaninate hydrochloride | HCID 3084017 | — |
| 生成物 | N-Acetyl-L-phenylalanine | HCID 74839 | — |
| 生成物 | (R)-Methyl 2-amino-3-phenylpropanoate | HCID 853474 | — |
反応手順
To 310 parts by volume of an aqueous 0.5N sodium hydroxide solution, heated to about 70°, is added, successively, 17.7 parts of N-acetyl-L-phenylalanine and 33.3 parts of DL-phenylalanine methyl ester hydrochloride. A precipitate forms and upon cooling and filtering, the salt of N-acetyl-L-phenylalanine and D-phenylalanine methyl ester is obtained. Recrystallization from hot water affords the pure salt exhibiting an [α]D in 0.5% water of about +32.2°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03941831 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-39fe7e25f49b420b9fc236a8b4116a5c |
| 出典メモ | uspto-grants-1976_03 |