Hydrochloric Acid → gamma-Thiomorpholinobutyric acid hydrochloride

HRID 267349ノート

反応式

HRID 267349 の反応式
[S:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][C:10]([O:12]C)=[O:11])[CH2:3][CH2:2]1.[ClH:14]>O>[ClH:14].[S:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21555513Methyl 4-Thiomorpholinobutyrate

生成物 1

HCID 70633382gamma-Thiomorpholinobutyric acid hydrochloride収率 91%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 28.0 g. (0.138 mole) of methyl γ-thiomorpholinobutyrate in 300 ml. of concentrated hydrochloric acid and 250 ml. of water was stirred and heated at reflux for 18 hours. The solvents were removed on a rotary evaporator to give a colorless residue which crystallized upon trituration with acetone. The solid was filtered, washed with acetone, and dried in vacuo to give 28.2 g. (91%) of the desired product as colorless crystals, m.p. 242°-245°C.

後処理

  1. temperatureheated
  2. temperatureat reflux for 18 hours
  3. customThe solvents were removed on a rotary evaporator
  4. customto give a colorless residue which
  5. customcrystallized upon trituration with acetone
  6. filtrationThe solid was filtered
  7. washwashed with acetone
  8. customdried in vacuo
  9. customto give 28.2 g

出典と根拠

ORDレコード
ord-94cd64d5e4ef404e92126d1a61c949e6
出典データセット
uspto-grants-1976_03
特許番号
US03941782

反応ノート

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