Potassium Hydroxide → N-(Piperidin-4-yl)pyridin-2-amine

HRID 26738ノート

反応式

HRID 26738 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][CH:8]1[CH2:13][CH2:12][N:11](C(OCC)=O)[CH2:10][CH2:9]1.[OH-].[K+]>CC(O)C>[NH:11]1[CH2:12][CH2:13][CH:8]([NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:9][CH2:10]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 11357119Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate

生成物 1

HCID 21912674N-(Piperidin-4-yl)pyridin-2-amine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of 90 parts of ethyl 4-(2-pyridinylamino)-1-piperidinecarboxylate, 90 parts of potassium hydroxide and 720 parts of 2-propanol is stirred and refluxed for 2 days. The reaction mixture is evaporated. 1000 Parts of water are added to the residue and the product is extracted with dichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 13 parts of N-(4-piperidinyl)-2-pyridinamine.

後処理

  1. temperaturerefluxed for 2 days
  2. customThe reaction mixture is evaporated
  3. addition1000 Parts of water are added to the residue
  4. extractionthe product is extracted with dichloromethane
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue is crystallized from 2,2'-oxybispropane

出典と根拠

ORDレコード
ord-01e4b8e38dab42e49a6afd56c1ffd7a7
出典データセット
uspto-grants-1979_04
特許番号
US04151286

反応ノート

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