Potassium Hydroxide → 2'-Chloro-4-biphenylylglycolic acid

HRID 267382ノート

反応式

HRID 267382 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([OH:20])[C:15]([O:17]CC)=[O:16])=[CH:10][CH:9]=1.[OH-].[K+]>C(O)(C)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([OH:20])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 21556089Ethyl 2'-chloro-4-biphenylylglycolate

生成物 1

HCID 215230142'-Chloro-4-biphenylylglycolic acid

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a solution of 0.144 moles of ethyl 2'-chloro-4-biphenylylglycolate dissolved in 220 ml. of isopropanol is added 38 g. (0.7 mole) of potassium hydroxide. This mixture is then heated at reflux temperature in a nitrogen atmosphere. The solution is concentrated in vacuo to a viscous oil, which is then dissolved in 500 ml. of water and filtered. The filtrate is acidified with 10% HCl and the precipitate is taken up in ether. The ether layer is dried, filtered and the filtrate concentrated to dryness. Recrystallization of residue from benzene-cyclohexane 1:1 gives 2'-chloro-4-biphenylylglycolic acid.

後処理

  1. temperatureThis mixture is then heated
  2. temperatureat reflux temperature in a nitrogen atmosphere
  3. concentrationThe solution is concentrated in vacuo to a viscous oil, which
  4. dissolutionis then dissolved in 500 ml
  5. filtrationof water and filtered
  6. dry with materialThe ether layer is dried
  7. filtrationfiltered
  8. concentrationthe filtrate concentrated to dryness
  9. customRecrystallization of residue from benzene-cyclohexane 1:1

出典と根拠

ORDレコード
ord-10f30f8f91ca40458e6a5415b9b15da9
出典データセット
uspto-grants-1976_03
特許番号
US03941821

反応ノート

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