2,6-Dimethylaniline → 1,3-Dioxolane-2-methanamine, N-(2,6-dimethylphenyl)-

HRID 267454

反応式

HRID 267454 の反応式
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH2:4].Cl[CH2:11][CH:12]1[O:16][CH2:15][CH2:14][O:13]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:13]1[CH2:14][CH2:15][O:16][CH:12]1[CH2:11][NH:4][C:3]1[C:5]([CH3:9])=[CH:6][CH:7]=[CH:8][C:2]=1[CH3:1]

参加物

5

反応物 3

HCID 68962,6-DimethylanilineHCID 11430Potassium CarbonateHCID 757272-(Chloromethyl)-1,3-dioxolane

生成物 1

HCID 1047101,3-Dioxolane-2-methanamine, N-(2,6-dimethylphenyl)-

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2,6-Dimethylaniline (75 grams), 2-chloromethyl-1,3-dioxolane (25 grams), potassium carbonate (34 grams) and dimethylformamide (50 ml) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at reflux for a period of about 18 hours. After this time the mixture was filtered and distilled to yield the desired product N-(1,3-dioxolan-2-ylmethyl)-2,6-dimethylaniline.

後処理

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureat reflux for a period of about 18 hours
  5. filtrationAfter this time the mixture was filtered
  6. distillationdistilled

出典と根拠

ORDレコード
ord-426ace5dda2648cfa90bd8c38b90c46c
出典データセット
uspto-grants-1976_03
特許番号
US03942972

関連ノート

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