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N-Bromoacetamide → Sodium (2-hydroxy-1-bromopropyl)-phosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Bromoacetamide | HCID 4353 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | P-(1Z)-1-Propen-1-ylphosphonic acid | HCID 6436667 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Sodium (2-hydroxy-1-bromopropyl)-phosphonate | HCID 86733120 | — |
反応手順
10.8 g. of cis-propenylphosphonic acid is dissolved in 50 ml. of water and the pH of the solution is adjusted to 4.2 by the addition of 2.5 N sodium hydroxide. 13.8 g. of N-bromoacetamide is added and the suspension is stirred at room temperature. The reaction is complete when the N-bromoacetamide is in solution and the mixture is negative to starch-iodide paper. The solution is lyophilized and the residue is triturated several times with chloroform to give sodium (2-hydroxy-1-bromopropyl)-phosphonate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03943153 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-d3df9ff839424b4a863354e31b5ebf93 |
| 出典メモ | uspto-grants-1976_03 |