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Isocyanic acid → 2,5-Bis(2-methylpropyl)-3,6-dimethylpyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isocyanic acid | HCID 6347 | — |
| 反応物 | 5-Methyl-2-hexanone | HCID 8034 | — |
| 反応物 | Nitrosyl chloride | HCID 17601 | — |
| 反応物 | 5-Methyl-3-oximino-2-hexanone | HCID 71443027 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2,5-Bis(2-methylpropyl)-3,6-dimethylpyrazine | HCID 585410 | — |
反応手順
f. 2,5-Dimethyl-3,6-diisobutyl-pyrazine was prepared by first forming 5-methyl-3-oximino-2-hexanone by reacting 5-methyl-2-hexanone with nitrosyl chloride according to the method of BOUVEAULT (loc.cit.). The autocondensation of two moles of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia 11, 310 (1957)] yielded 2,5-dimethyl-3,6-diisobutyl-pyrazine which had a b.p. of 69°-70°C./0.01 mm. Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03943260 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-c02c1a20fbbe48769e87f275453a631b |
| 出典メモ | uspto-grants-1976_03 |