Hydrochloric Acid → 3-(Benzyloxy)benzene-1,2-diol
反応式
COC1(C)[O:7][C:6]2[CH:8]=[CH:9][CH:10]=[C:11]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:5]=2[O:4]1.Cl>CO>[CH2:13]([O:12][C:11]1[CH:10]=[CH:9][CH:8]=[C:6]([OH:7])[C:5]=1[OH:4])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1参加物
4
実験手順
A mixture of 2-methoxy-2-methyl-4-benzyloxy-1,3-benzodioxole (13.6 g., 0.05 mole), methanol (210 ml.) and 5N hydrochloric acid (210 ml.) is stirred under reflux in an atmosphere of nitrogen for 10 hours. Most of the methanol is distilled off under vacuum and the product then extracted with ether. The ethereal solution is washed with water, dried over magnesium sulfate followed by calcium sulfate and evaporated to dryness to yield the crude 3-benzyloxy-catechol which can be recrystallized from di-isopropyl ether.
後処理
- temperatureunder reflux in an atmosphere of nitrogen for 10 hours
- distillationMost of the methanol is distilled off under vacuum
- extractionthe product then extracted with ether
- washThe ethereal solution is washed with water
- dry with materialdried over magnesium sulfate
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-cf8fe09b4d854d44912f7654216a4cc3
- 出典データセット
- uspto-grants-1976_03
- 特許番号
- US03944560
反応ノート
読み込み中…