Potassium Carbonate → 2-Phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile

HRID 267792

反応式

HRID 267792 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[O:4][CH2:5][C:6]#[N:7].Cl[CH:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:16]1([CH:13]([O:1][C:2]2[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=2[O:4][CH2:5][C:6]#[N:7])[C:14]#[N:15])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

5

反応物 3

HCID 11430Potassium Carbonate2 回HCID 123763172-Chloro-2-phenylacetonitrile2 回HCID 215539352-(2-Hydroxyphenoxy)acetonitrile

生成物 1

HCID 215539672-Phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2-(2-hydroxyphenoxy)acetonitrile (14.9 g., 0.1 mole), 2-chloro-2-phenylacetonitrile (15.2 g., 0.1 mole), finely powdered potassium carbonate (13.8 g., 0.1 mole) and 80 ml. of acetone is refluxed 3 hours. The mixture is then treated with 2-chloro-2-phenylacetonitrile (7.6 g., 0.05 mole) and potassium carbonate (6.9 g., 0.5 mole) and refluxed six hours. The mixture is filtered, the solids washed with acetone and the combined filtrate evaporated in vacuo to give an oil. Crystallization of the oil affords 2-phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile.

後処理

  1. temperaturerefluxed six hours
  2. filtrationThe mixture is filtered
  3. washthe solids washed with acetone
  4. customthe combined filtrate evaporated in vacuo
  5. customto give an oil
  6. customCrystallization of the oil

出典と根拠

ORDレコード
ord-fb7af966e19f41d4a3a52ead66b7bcdc
出典データセット
uspto-grants-1976_03
特許番号
US03944560

関連ノート

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