O-Xylene → 5-Fluoro-2-methylindan-1-one

HRID 267822

反応式

HRID 267822 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:13])[CH:9]([CH3:12])[CH2:10]O)=[CH:4][CH:3]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.C1(C)C(C)=CC=CC=1>O>[F:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[C:8](=[O:13])[CH:9]([CH3:12])[CH2:10]2

参加物

5

反応物 3

HCID 7237O-XyleneHCID 14812Phosphorus oxide (P4O10)HCID 215218911-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one

生成物 1

HCID 30162575-Fluoro-2-methylindan-1-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for one hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

後処理

  1. additionA mixture of 18.2 g
  2. temperatureThe reaction is cooled
  3. washthe xylene layer is washed with aqueous sodium hydroxide and water
  4. concentrationThe organic layer is then concentrated in vacuo

出典と根拠

ORDレコード
ord-e35a1b1b9bd74744aba18c195be0050a
出典データセット
uspto-grants-1976_03
特許番号
US03944600

関連ノート

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