Aluminum(III) Chloride → 5-Fluoro-2-methylindan-1-one

HRID 267824ノート

反応式

HRID 267824 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].Br[C:6]([CH3:17])([CH3:16])[C:7]([C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)=[O:8]>C(=S)=S>[F:15][C:12]1[CH:11]=[C:10]2[C:9](=[CH:14][CH:13]=1)[C:7](=[O:8])[CH:6]([CH3:17])[CH2:16]2

参加物

4

反応物 2

HCID 6451240Aluminum(III) ChlorideHCID 131131752-Bromo-1-(4-fluorophenyl)-2-methylpropan-1-one

生成物 1

HCID 30162575-Fluoro-2-methylindan-1-one

試薬・触媒・溶媒 1

HCID 6348Carbon Disulfide溶媒

反応条件

温度
50 °C

実験手順

To a slurry of 120.2 g. (0.90 mole) of anhydrous aluminum chloride in 54 ml. of carbon disulfide is added 122.6 g. (0.50 mole) of 2-bromo-4'-fluoro-2-methylpropiophenone at 15°-20°C over one hour. The mixture is warmed to 50°C over one hour, stirred at 50°C for three hours and quenched in ice. The product is extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

後処理

  1. customquenched in ice
  2. extractionThe product is extracted into toluene
  3. washThe toluene layer is washed with aqueous sodium hydroxide and water
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1be104609f2e4b2e8727f3bf567c65de
出典データセット
uspto-grants-1976_03
特許番号
US03944600

反応ノート

読み込み中…