Aluminum(III) Chloride → 5-Fluoro-2-methylindan-1-one

HRID 267825

反応式

HRID 267825 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[C:9]([CH3:11])=[CH2:10])=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[C:8](=[O:12])[CH:9]([CH3:11])[CH2:10]2

参加物

4

反応物 2

HCID 6451240Aluminum(III) ChlorideHCID 132782011-(4-Fluorophenyl)-2-methylprop-2-en-1-one

生成物 1

HCID 30162575-Fluoro-2-methylindan-1-one

試薬・触媒・溶媒 1

HCID 6348Carbon Disulfide溶媒

反応条件

温度
45 °C

実験手順

Fifty grams (0.30 moles) of 4'-fluoro-2-methylacrylophenone is added to a slurry of 60.1 g. (0.45 moles) of anhydrous aluminum chloride in 27 ml. of carbon disulfide at 20°-25°C over one hour. The mixture is heated to 45°C over one hour and stirred at 45°C for one hour. The reaction is quenched in ice. The oily aqueous layer is extracted with toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

後処理

  1. customThe reaction is quenched in ice
  2. extractionThe oily aqueous layer is extracted with toluene
  3. washThe toluene layer is washed with aqueous sodium hydroxide and water
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1ff83bf6febf4d849c5a367efe41df33
出典データセット
uspto-grants-1976_03
特許番号
US03944600

関連ノート

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