Sulfuric Acid → 5-Fluoro-2-methylindan-1-one

HRID 267829ノート

反応式

HRID 267829 の反応式
CN(C)[CH2:3][CH:4]([CH3:14])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=[O:6].S(=O)(=O)(O)O>>[F:13][C:10]1[CH:9]=[C:8]2[C:7](=[CH:12][CH:11]=1)[C:5](=[O:6])[CH:4]([CH3:14])[CH2:3]2

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 215218873-(Dimethylamino)-1-(4-fluorophenyl)-2-methylpropan-1-one

生成物 1

HCID 30162575-Fluoro-2-methylindan-1-one

反応条件

温度
90 °C

実験手順

A mixture of 42 g. (0.20 mole) of 3-dimethylamino-4'-fluoro-2-methylpropiophenone and 100 ml. of concentrated sulfuric acid is warmed to 90°C over one hour and stirred at 90°C for two hours. The reaction is cooled and quenched in ice and the product extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

後処理

  1. additionA mixture of 42 g
  2. temperatureThe reaction is cooled
  3. customquenched in ice
  4. extractionthe product extracted into toluene
  5. washThe toluene layer is washed with aqueous sodium hydroxide and water
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-50c7515c35324b5c9820dbf91855b0db
出典データセット
uspto-grants-1976_03
特許番号
US03944600

反応ノート

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