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1,3-Cyclohexanedione → 2-Amino-4-(biphenyl-2-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Cyclohexanedione | HCID 10434 | — |
| 反応物 | (1,1'-Biphenyl)-2-carboxaldehyde | HCID 121052 | — |
| 反応物 | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Amino-4-(biphenyl-2-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester | HCID 12391115 | 45% |
反応手順
Upon heating a solution of 6.1 g of biphenyl-2-aldehyde, 3.8 g of cyclohexane-1,3-dione and 5.1 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 1 hour, 2-amino-4-(biphenyl-2-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point 248°C (ethanol) is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03946026 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-80556131a437473c9cbb2b539be94f07 |
| 出典メモ | uspto-grants-1976_03 |