Sulfuric Acid → Propionic acid, 2-mercapto-, isopropyl ester

HRID 268109

反応式

HRID 268109 の反応式
[C:1]([OH:6])(=S)[CH:2]([CH3:4])O.O[S:8](O)(=O)=O.[CH:12]([OH:15])([CH3:14])[CH3:13]>>[CH:12]([O:15][C:1](=[O:6])[CH:2]([SH:8])[CH3:4])([CH3:14])[CH3:13]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 178473673HCID 178473673、化合物

生成物 1

HCID 537500Propionic acid, 2-mercapto-, isopropyl ester

実験手順

To a suitable reaction vessel equipped with a thermometer, agitator and venting means are charged approximately 500 parts by weight of isopropyl alcohol and approximately 53 parts by weight of thiolactic acid (about 1/2 mole). To the so-charged mass is added about 1 part by weight of concentrated H2SO4. The contents of the so-charged vessel are heated with agitation under a nitrogen atmosphere to reflux temperature and maintained at that temperature for about 4 hours. The contents are cooled to about room temperature. Excess alcohol is stripped off by distillation under vacuum. The liquid product may be vacuum distilled if a high purity product is desired. Isopropyl-alpha-mercapto-propionate is obtained.

後処理

  1. customTo a suitable reaction vessel equipped with a thermometer, agitator and venting means
  2. temperatureThe contents of the so-charged vessel are heated with agitation under a nitrogen atmosphere
  3. temperatureto reflux temperature
  4. temperaturemaintained at that temperature for about 4 hours
  5. temperatureThe contents are cooled to about room temperature
  6. distillationExcess alcohol is stripped off by distillation under vacuum
  7. distillationdistilled if a high purity product

出典と根拠

ORDレコード
ord-178521aaf6fb40f59eb0f6d3208da51b
出典データセット
uspto-grants-1976_03
特許番号
US03946071

関連ノート

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