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Isopropanol → Bis(3-diethylaminopropyl) 9-ethylcarbazole-3,6-dicarboxylate dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 3-Chloropropyl(diethyl)amine | HCID 66918 | — |
| 反応物 | 9-ethyl-9H-carbazole-3,6-dicarboxylic acid | HCID 3797914 | — |
| 触媒 | Benzyltrimethylammonium chloride | HCID 5963 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Bis(3-diethylaminopropyl) 9-ethylcarbazole-3,6-dicarboxylate dihydrochloride | HCID 12331707 | — |
反応手順
To 250 ml of isopropanol is added 10.0 g (0.035 mole) of 9-ethylcarbazole-3,6-dicarboxylic acid, 21.2 g (0.14 mole) of 3-diethylaminopropylchloride and 0.5 ml of 60% aqueous benzyltrimethylammonium chloride. The solution is heated at reflux for 2 hours with stirring and then allowed to stir overnight at room temperature. Addition of ether to the reaction mixture gives a crystalline product which is recrystallized twice from methanol-acetone to give bis(3-diethylaminopropyl)-9-ethylcarbazole-3,6-dicarboxylate dihydrochloride. M.P. 233°-234°C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03946112 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-c731bbd411ca405b9cb59a8a9db8cc07 |
| 出典メモ | uspto-grants-1976_03 |