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L-Proline → 10-Ethyl-1,2,3,5,10,11 a-hexahydro-11H-pyrrolo[2,1-c] [1,4] benzodiazepin-11-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Proline | HCID 145742 | — |
| 反応物 | 5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione | HCID 301358 | — |
| 反応物 | N-ethylisatoic anhydride | HCID 3249856 | — |
| 反応物 | 10-ethyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione | HCID 17035871 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 10-Ethyl-1,2,3,5,10,11 a-hexahydro-11H-pyrrolo[2,1-c] [1,4] benzodiazepin-11-one | HCID 45095747 | — |
反応手順
When (+) 10-ethyl-1,2,3,11a-tetrahydro-5 H-pyrrolo[2,1-c] [1,4] benzodiazepin-5,11(10H)-dione, melting point 138° -140°C., (prepared as described above by reacting N-ethylisatoic anhydride with L-proline) is substituted for (+)-1,2,3,11 a-tetrahydro-10-methyl-[5H-pyrrolo [2,1-c] [1,4] benzodiazepin-5,11 -(10H)-dione in the procedure of Example 1, the above compound is obtained. The hydrochloride salt melts at 233°-235°C., [α]D 25 + 415° (0.9% in methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03947408 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-7c3b250014054028ae1647fcb20c6b75 |
| 出典メモ | uspto-grants-1976_03 |