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Cysteamine Hydrochloride → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cysteamine Hydrochloride | HCID 9082 | — |
| 反応物 | 4-Methylimidazol-5-ylmethanolhydrochloride | HCID 3084707 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride | HCID 3015999 | 184.6% |
反応手順
(i)(a) A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in acetic acid (200 ml.) was heated under reflux for 10 hours. Following cooling to 15°-20°, the solid which crystallised was collected and washed with isopropyl alcohol to give 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (45.5 g.), m.p. 189°-192°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04151288 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-6ef02c204531486b9758f3aef7927054 |
| 出典メモ | uspto-grants-1979_04 |