p-Aminopropiophenone → HCID 178458498、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[ClH:12].N([C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]3[N:32]=[CH:31][NH:30][C:28]3=2)[N:23]=[C:22]([CH3:33])[CH:21]=1)C1C=CC=CC=1>C(O)C>[ClH:12].[C:8]([C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[C:27]4[N:32]=[CH:31][NH:30][C:28]4=3)[N:23]=[C:22]([CH3:33])[CH:21]=2)=[CH:7][CH:6]=1)(=[O:11])[CH2:9][CH3:10]参加物
4
実験手順
A mixture containing 14.9 g. (0.1 m) of p-aminopropiophenone 21.7 g. (0.1 m.) of the compound of Example I, C. and 500 ml. of ethanol was refluxed with stirring overnight. It was then concentrated in vacuo to give 34 g. m.p. 287°-289°, complete 320°C. The crude product was recrystallized from 1000 ml. of MeOH to yield 27 g.m.p. softens 318°, melts 328°-330°C.
後処理
- additionA mixture containing 14.9 g