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Ammonia → 2-Amino-1-(3-nitrophenyl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | m-Nitroacetophenone | HCID 8494 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 生成物 | 2-Amino-1-(3-nitrophenyl)ethanol | HCID 18628156 | — |
反応手順
3-Nitroacetophenone is brominated in the α-position, the bromination product is reduced by means of sodium borohydride to the corresponding bromohydride and this is treated with ammonia. There is obtained rac.-α-(aminomethyl)-3-nitrobenzyl alcohol which melts at 107°-108° (softening from 105°) after crystallization from ethyl acetate-ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03947456 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-43b11491cddd49dd992e9585706b5712 |
| 出典メモ | uspto-grants-1976_03 |