Hydrochloric Acid → Phenylpropanolamine

HRID 268303

反応式

HRID 268303 の反応式
[CH3:1][C@H:2]([NH2:11])[C@@H:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>>[CH3:1][C@H:2]([NH2:11])[C@H:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 441457Cathine

生成物 1

HCID 10297Phenylpropanolamine収率 105.7%

実験手順

61 grams of this salt were split in a manner analogous to that described in example 1. There were obtained 33 grams of L-3-formyl-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid melting at 179° - 180°C.; [α]D20 - 54.4° as well as 26.5 grams of d-phenylpropanolamine.HCl melting point 173°C.; [α]D20 + 33°. From the mother liquor of the racemate splitting by evaporation to dryness and treatment with isopropanolic HCl there were obtained 28 grams (77%) of l-phenylpropanolamine.HCl, melting point 179°C.; [α]D20 - 31.4°.

後処理

  1. custom[α]D20 + 33°
  2. customFrom the mother liquor of the racemate splitting by evaporation to dryness and treatment with isopropanolic HCl there

出典と根拠

ORDレコード
ord-14fee53e9c514cb1ac088373d509f9f5
出典データセット
uspto-grants-1976_03
特許番号
US03947464

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