化工社化工社 化学情報印刷レポート · 研究参考用
Sulfuric Acid → 2H-1-Benzopyran-6-ol, 3,4-dihydro-2-methoxy-2,5,7,8-tetramethyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Methyl vinyl ketone | HCID 6570 | — |
| 反応物 | Trimethyl orthoformate | HCID 9005 | — |
| 反応物 | Trimethylhydroquinone | HCID 12785 | — |
| 反応物 | 2-Methoxy-1,3-butadiene | HCID 99338 | — |
| 反応物 | 4-Hydroxy-2-Butanone | HCID 111509 | — |
| 反応物 | 2-Butanone, 4-methoxy- | HCID 138889 | — |
| 反応物 | 3,3-Dimethoxybut-1-ene | HCID 13028910 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2H-1-Benzopyran-6-ol, 3,4-dihydro-2-methoxy-2,5,7,8-tetramethyl- | HCID 103763 | — |
反応手順
In the manner described in Example 1, 3.80 g (25 mmol) samples of trimethylhydroquinone were treated in 25 ml of methanol, 5.0 ml of trimethyl orthoformate, and 0.10 ml of 36 N aqueous H2SO4 with 50 mmole portions of the following methyl vinyl ketone substitutes: a, 2-methoxybutadiene; b, 3-ketobutanol; c, 3,3-dimethoxybutene (contaminated with about 20 percent 2-methoxybutadiene); and d, 4-methoxy-2-butanone. The reactions were monitored by tlc. Reactions a,c and d were complete after 24 hr and were worked up and dried in the manner of Example 1 to give (±)-6-hydroxy-2-methoxy-2,5,7,8-tetramethylchroman. In reaction b, a>50 percent conversion to (±)-6-hydroxy-2-methoxy-2,5,7,8-tetramethylchroman was indicated by tlc.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03947473 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-7499afe1cbc242abbe87599304411fec |
| 出典メモ | uspto-grants-1976_03 |