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Dimethyl Sulfoxide → (+/-)-6-Benzyloxy-2-methoxy-2,5,7,8-tetramethylchroman
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2H-1-Benzopyran-6-ol, 3,4-dihydro-2-methoxy-2,5,7,8-tetramethyl- | HCID 103763 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (+/-)-6-Benzyloxy-2-methoxy-2,5,7,8-tetramethylchroman | HCID 14415660 | — |
反応手順
A mixture of 70.8 g. of (±)-6-hydroxy-2-methoxy-2,5,7,8-tetramethylchroman, 90.9 g. of anhydrous potassium carbonate, 300 ml. of dimethylsulfoxide and 69 ml. of benzyl chloride was stirred at 23° under N2 for 24 hours. The suspension was poured into water and extracted with ether. The ether solutions were washed with brine, dried over sodium sulfate and stripped of solvent to give (±)-6-benzyloxy-2-methoxy-2,5,7,8-tetramethylchroman as an oil which solidified to a light yellow mass, m.p. 70°-72.5°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03947473 |
| 出典データセット | uspto-grants-1976_03 |
| ORD ID | ord-6f8275b7ff9d4d8f90f989ea0ff322cf |
| 出典メモ | uspto-grants-1976_03 |