Acetyl chloride → Phenyl acetate

HRID 268510

反応式

HRID 268510 の反応式
[O-:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8](Cl)(=[O:10])[CH3:9]>CCOCC>[C:8]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:10])[CH3:9]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 119047Phenolate

生成物 1

HCID 31229Phenyl acetate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A vigorously stirred suspension of thallous phenoxide (5 g., 0.017 m.) in anhydrous ether (15 ml.) is treated dropwise with freshly distilled acetyl chloride (1.33 g., 0.017 m.) in anhydrous ether (3 ml.) over 5 mins. at such a rate that the exothermic reaction is controlled. The mixture is then stirred for 1 hour at room temperature, the precipitated thallous chloride removed by filtration through Celite and the solvent evaporated under vacuum. The residual colorless oil is distilled to give phenyl acetate, 2.27 g., 98%, b.p. 110°/58 mm.

後処理

  1. customat such a rate that the exothermic reaction
  2. customthe precipitated thallous chloride
  3. customremoved by filtration through Celite
  4. customthe solvent evaporated under vacuum
  5. distillationThe residual colorless oil is distilled

出典と根拠

ORDレコード
ord-52748cb56aef414f9320e2f419e3bd4b
出典データセット
uspto-grants-1976_03
特許番号
US03947488

関連ノート

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