Hydrazine → 3-Amino-6-chloro-3,4-dihydro-4-phenylquinazolin-4-ol
反応式
[C:1]([C:9]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:10]=1[NH:11][CH:12]=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:19][NH2:20]>C(O)C>[NH2:19][N:20]1[C:1]([OH:8])([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]2[C:10](=[CH:14][CH:15]=[C:16]([Cl:18])[CH:17]=2)[N:11]=[CH:12]1参加物
4
実験手順
A mixture of 0.1 mole of 2'-benzoyl-4'-chloroformanilide and 0.15 mole of hydrazine are stirred at room temperature in ethanol. Stirring is continued for 20 hours. The reaction mixture is chilled, and the precipitate filtered. The solid is washed and recrystallized from dimethylformamide to give 3-amino-6-chloro-3,4-dihydro-4-hydroxy-4-phenylquinazoline.
後処理
- temperatureThe reaction mixture is chilled
- filtrationthe precipitate filtered
- washThe solid is washed
- customrecrystallized from dimethylformamide
出典と根拠
- ORDレコード
- ord-66b31b2810e14ea4b091bff004316bca
- 出典データセット
- uspto-grants-1976_03
- 特許番号
- US03947466
反応ノート
読み込み中…