関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N-(2-Hydroxyethyl)ethylenediamine | HCID 8112 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | Benzene, 1-fluoro-2-methyl-4-nitro- | HCID 68001 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 58598928 | HCID 58598928 | 77.8% |
反応手順
2 g of 4-fluoro-3-methyl nitrobenzene, 1.61 g of 2-(2-aminoethylamino)ethanol and 2.14 g of K2CO3 were added to a solution of 20 ml of N-methylpyrrolidinone. The reaction medium was heated at 60° C. for 7 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 2.4 g of 2-[2-(4-nitro-2-methylphenylamino)ethylamino]ethanol (5) were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07445645B2 |
|---|
| 出典データセット | uspto-grants-2008_11 |
|---|
| ORD ID | ord-380b56030e494935b169924ff1029747 |
|---|
| 出典メモ | uspto-grants-2008_11 |
|---|
