N-(2-Hydroxyethyl)ethylenediamine → HCID 58598934、化合物

HRID 268554

反応式

HRID 268554 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=1.[NH2:12][CH2:13][CH2:14][NH:15][CH2:16][CH2:17][OH:18].C([O-])([O-])=O.[K+].[K+].CN1CCCC1=O>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:12][CH2:13][CH2:14][NH:15][CH2:16][CH2:17][OH:18])=[CH:3][C:4]=1[CH3:11])([O-:10])=[O:9]

参加物

6

反応物 4

HCID 8112N-(2-Hydroxyethyl)ethylenediamineHCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 949565-Fluoro-2-nitrotoluene

生成物 1

HCID 58598934HCID 58598934、化合物収率 42.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

2 g of 4-fluoro-2-methyl-nitrobenzene, 1.61 g of 2-(2-aminoethylamino)ethanol and 2.14 g of K2CO3 were added to a solution of 20 ml of N-methylpyrrolidinone. The reaction medium was heated at 60° C. for 7 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 1.3 g of 2-[2-(4-nitro-3-methylphenylamino)ethylamino]ethanol (7) were obtained.

後処理

  1. temperatureafter cooling to room temperature
  2. customThe yellow precipitate formed
  3. filtrationwas filtered off
  4. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-e982f9053cdf4e2d9fe521cdd5ec4128
出典データセット
uspto-grants-2008_11
特許番号
US07445645B2

関連ノート

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