関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | Benzene, 1-fluoro-2-methyl-4-nitro- | HCID 68001 | — |
| 反応物 | 2-Butanol, 4-amino- | HCID 170254 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(4-Nitro-2-methylphenylamino)butan-2-ol | HCID 23104308 | 82.3% |
反応手順
2 g of 2-fluoro-5-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.38 g of 4-amino-2-butanol and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 2.38 g of 4-(4-nitro-2-methylphenylamino)butan-2-ol (27) were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07445645B2 |
|---|
| 出典データセット | uspto-grants-2008_11 |
|---|
| ORD ID | ord-4da51da5a808409a865b320d3e83debe |
|---|
| 出典メモ | uspto-grants-2008_11 |
|---|
