関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | 5-Fluoro-2-nitrotoluene | HCID 94956 | — |
| 反応物 | 2-Butanol, 4-amino- | HCID 170254 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(4-Nitro-3-methylphenylamino)butan-2-ol | HCID 23104300 | 99.6% |
反応手順
2 g of 5-fluoro-2-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.38 g of 4-amino-2-butanol and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 10 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 2.88 g of 4-(4-nitro-3-methylphenylamino)butan-2-ol (31) were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07445645B2 |
|---|
| 出典データセット | uspto-grants-2008_11 |
|---|
| ORD ID | ord-06ad4cc3d0ec4d17b0de31598f582ee1 |
|---|
| 出典メモ | uspto-grants-2008_11 |
|---|
