Potassium Carbonate → Tert-butyl-7-[(2-phenyl-5-methyl-1,3-oxazol-4-yl)methoxy]chromane-3-carboxylate

HRID 268699ノート

反応式

HRID 268699 の反応式
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[O:6][C:7]=1[CH3:8].C(=O)([O-])[O-].[K+].[K+].[OH:21][C:22]1[CH:31]=[C:30]2[C:25]([CH2:26][CH:27]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:28][O:29]2)=[CH:24][CH:23]=1>O>[C:35]([O:34][C:32]([CH:27]1[CH2:26][C:25]2[C:30](=[CH:31][C:22]([O:21][CH2:2][C:3]3[N:4]=[C:5]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=4)[O:6][C:7]=3[CH3:8])=[CH:23][CH:24]=2)[O:29][CH2:28]1)=[O:33])([CH3:38])([CH3:36])[CH3:37]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 97942894-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazoleHCID 59832111Tert-butyl 7-hydroxychromane-3-carboxylate

生成物 1

HCID 69279834Tert-butyl-7-[(2-phenyl-5-methyl-1,3-oxazol-4-yl)methoxy]chromane-3-carboxylate収率 71.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred solution of 4-(chloromethyl)-5-methyl-2-phenyl-1,3-oxazole (103.5 mg, 0.5 mmol) and potassium carbonate (138.4 mg, 1 mmol), tert-butyl 7-hydroxychromane-3-carboxylate (125 mg, 0.5 mmol) was added and the reaction mixture was stirred at room temperature for 48 hrs. Water (50 ml) was added and the precipitated product was extracted with 25 ml of diethyl ether. Ether layer was washed with water (25 ml) twice and dried. On evaporation of solvent, the product was obtained as pale yellow gum (150 mg, 36%).

後処理

  1. extractionthe precipitated product was extracted with 25 ml of diethyl ether
  2. washEther layer was washed with water (25 ml) twice
  3. customdried
  4. customOn evaporation of solvent

出典と根拠

ORDレコード
ord-8312fd09f0f741928d9a29f2500a4296
出典データセット
uspto-grants-2008_11
特許番号
US07446127B2

反応ノート

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