Potassium Carbonate → Tert-butyl-7-[(2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl)methoxy]chromane-3-carboxylate

HRID 268701ノート

反応式

HRID 268701 の反応式
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][O:9]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Br:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[O:33][C:34]([CH3:39])=[C:35]([CH2:37]Cl)[N:36]=2)=[CH:28][CH:27]=1>O>[C:15]([O:14][C:12]([CH:7]1[CH2:6][C:5]2[C:10](=[CH:11][C:2]([O:1][CH2:37][C:35]3[N:36]=[C:32]([C:29]4[CH:30]=[CH:31][C:26]([Br:25])=[CH:27][CH:28]=4)[O:33][C:34]=3[CH3:39])=[CH:3][CH:4]=2)[O:9][CH2:8]1)=[O:13])([CH3:18])([CH3:17])[CH3:16]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 109571082-(4-Bromophenyl)-4-(chloromethyl)-5-methyloxazoleHCID 59832111Tert-butyl 7-hydroxychromane-3-carboxylate

生成物 1

HCID 69279608Tert-butyl-7-[(2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl)methoxy]chromane-3-carboxylate収率 77.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

To a stirred suspension of tert-butyl 7-hydroxychromane-3-carboxylate (1.1 g, 4.4 mmol) and potassium carbonate (1.1 g, 8 mmol), 2-(4-bromophenyl)-4-(chloromethyl)-5-methyl-1,3-oxazole (1.14 g, 4 mmol) was added and the reaction mixture was stirred at 60° C. for overnight. After the completion of the reaction, water (40 ml) was added and the precipitated product was extracted with ethylacetate (60 ml). The organic layer was washed with 50 ml of water twice and dried. The dried solution was evaporated to give the product as brown solid (1.55 g, 77.4%).

後処理

  1. additionwas added
  2. additionwas added
  3. extractionthe precipitated product was extracted with ethylacetate (60 ml)
  4. washThe organic layer was washed with 50 ml of water twice
  5. customdried
  6. customThe dried solution was evaporated

出典と根拠

ORDレコード
ord-a3d340ab3ed64250b45df0e7cea8363c
出典データセット
uspto-grants-2008_11
特許番号
US07446127B2

反応ノート

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