Hydrochloric Acid → 2-Chloro-4-(piperidin-4-yloxy)-benzonitrile hydrochloride

HRID 268724ノート

反応式

HRID 268724 の反応式
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 17986305HCID 17986305、化合物

生成物 1

HCID 179862902-Chloro-4-(piperidin-4-yloxy)-benzonitrile hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

2-Chloro-4-[(1-tert-butoxycarbonyl-4-piperidinyl)oxy]benzonitrile (D29) (5.0 g) was dissolved in methanol (150 ml) and 4N HCl in dioxane (100 ml) was added. The reaction stirred at rt overnight. The reaction mixture was then evaporated to give the title compound (D30) as a white solid (4.0 g).

後処理

  1. customThe reaction mixture was then evaporated

出典と根拠

ORDレコード
ord-5f60f505214a4d989575c79bb5cceb03
出典データセット
uspto-grants-2008_11
特許番号
US07446103B2

反応ノート

読み込み中…