3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(3-Cyano-6-methoxy-1H-indol-4-yl)-3-phenyl-acrylic acid ethyl ester
反応式
Br[C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]2[C:3]=1[C:4]([C:13]#[N:14])=[CH:5][NH:6]2.[CH2:15]([O:17][C:18](=[O:38])[CH:19]=[C:20](C1C=CC=C2C=1C(C#N)=CN2)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH3:16]>>[CH2:15]([O:17][C:18](=[O:38])[CH:19]=[C:20]([C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]2[C:3]=1[C:4]([C:13]#[N:14])=[CH:5][NH:6]2)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH3:16]参加物
3
実験手順
3-(3-Cyano-6-methoxy-1H-indol-4-yl)-3-phenyl-acrylic acid ethyl ester CXXIX (0.81 g, 54% yield) was prepared from 4-bromo-6-methoxy-1H-indole-3-carbonitrile using the procedure described above for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).
出典と根拠
- ORDレコード
- ord-f6156bbe77784488b66c0fbc9dd88712
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07446118B2
反応ノート
読み込み中…