Ethylenediamine → N-Methyl-N'-[2-(3-isothiazolylmethylamino)ethyl]urea

HRID 26888ノート

反応式

HRID 26888 の反応式
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][NH:7][CH2:8][CH2:9][NH2:10])=[N:2]1.C(N)CN.BrCC1C=CSN=1.[CH3:22][N:23]=[C:24]=[O:25]>>[CH3:22][NH:23][C:24]([NH:10][CH2:9][CH2:8][NH:7][CH2:6][C:3]1[CH:4]=[CH:5][S:1][N:2]=1)=[O:25]

参加物

5

反応物 4

HCID 3301EthylenediamineHCID 12228Methyl IsocyanateHCID 130375983-(bromomethyl)IsothiazoleHCID 20557777N-(3-isothiazolylmethyl)ethylenediamine

生成物 1

HCID 20557581N-Methyl-N'-[2-(3-isothiazolylmethylamino)ethyl]urea

実験手順

N-(3-Isothiazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 3-bromomethylisothiazole by the procedure of Example 40(a), is reacted with methyl isocyanate by the procedure of Example 24 to give, after concentrating and separating by column chromatography, the title compound.

後処理

  1. customto give
  2. concentrationafter concentrating
  3. customseparating by column chromatography

出典と根拠

ORDレコード
ord-fe698912d47b499d8d612bdfb135dcf8
出典データセット
uspto-grants-1979_04
特許番号
US04151288

反応ノート

読み込み中…