関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | Esculin | HCID 5281417 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-benzyloxy-6-D-glucosyloxycoumarin | HCID 22884042 | 86.4% |
反応手順
Esculin (1.0 g), benzyl chloride (1.0 g), potassium carbonate (0.7 g), catalytic amounts of 18-crown-6-ether and potassium iodide, and dimethylformamide (40 ml) were placed in an eggplant-shaped flask (100 ml). The mixture was reacted while stirred at 60° C. for 8 hours. The reaction mixture was concentrated under reduced pressure and the residue was poured into ice water. The precipitated crystals were filtered out and recrystallized from methanol to obtain 7-benzyloxy-6-D-glucopyranosyloxycoumarin (VIII-2) (melting point=184° to 186° C., mass spectrum (M+)=430, yield=86.4%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05731293 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-3d0d762737d34c2080eeda70e521dbc7 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
