1,3-Propanediamine → 2-(3-Aminopropylamino)-1,3,4-thiadiazole

反応式

Br[C:2]1[S:3][CH:4]=[N:5][N:6]=1.[NH2:7][CH2:8][CH2:9][CH2:10][NH2:11]>>[NH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:2]1[S:3][CH:4]=[N:5][N:6]=1

参加物

反応物 2

HCID 4281,3-Propanediamine

HCID 27951982-Bromo-1,3,4-thiadiazole

生成物 1

HCID 205577472-(3-Aminopropylamino)-1,3,4-thiadiazole

実験手順

By the procedure of Example 188, 2-bromo-1,3,4-thiadiazole is reacted with 1,3-diaminopropane to give 2-(3-aminopropylamino)-1,3,4-thiadiazole and this intermediate is reacted with methyl isothiocyanate to give N-methyl-N'-[3-(2-(1,3,4-thiadiazolyl)amino)propyl]thiourea.

出典と根拠

ORDレコード: ord-f07c7603ba174472ba4418e05a30098a
出典データセット: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04151288

反応ノート

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