Ethylenediamine → N-(2-Dimethylaminoethyl)-N'-[2-(2-benzimidazolylmethylamino)-ethyl]thiourea

HRID 26896

反応式

HRID 26896 の反応式
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[CH2:10][NH:11][CH2:12][CH2:13][NH2:14].C(N)CN.ClCC1NC2C=CC=CC=2N=1.[CH3:30][N:31]([CH3:37])[CH2:32][CH2:33][N:34]=[C:35]=[S:36]>>[CH3:30][N:31]([CH3:37])[CH2:32][CH2:33][NH:34][C:35]([NH:14][CH2:13][CH2:12][NH:11][CH2:10][C:2]1[NH:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)=[S:36]

参加物

5

反応物 4

HCID 3301EthylenediamineHCID 785712-ChloromethylbenzimidazoleHCID 3853726(2-Isothiocyanatoethyl)dimethylamineHCID 15365342N1-((1H-Benzo[d]imidazol-2-yl)methyl)ethane-1,2-diamine

生成物 1

HCID 54373380N-(2-Dimethylaminoethyl)-N'-[2-(2-benzimidazolylmethylamino)-ethyl]thiourea

実験手順

N-(2-Benzimidazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 2-chloromethylbenzimidazole by the procedure of Example 40, is reacted with 2-dimethylaminoethyl isothiocyanate by the procedure of Example 40 to give the title compound.

出典と根拠

ORDレコード
ord-54c3feb3870144ec9e983524851de7e2
出典データセット
uspto-grants-1979_04
特許番号
US04151288

関連ノート

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