Pyrazol-3-ylamine → HCID 178515606、化合物

HRID 268990

反応式

HRID 268990 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]([O:12]CC)=O)=[CH:4][CH:3]=1.[N:16]1[NH:17][C:18]([NH2:21])=[CH:19][CH:20]=1>CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([OH:12])[N:17]3[N:16]=[CH:20][CH:19]=[C:18]3[N:21]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 74561Pyrazol-3-ylamineHCID 101336Ethyl 3-(4-chlorophenyl)-3-oxopropanoate

生成物 1

HCID 178515606HCID 178515606、化合物収率 75.1%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
150 °C

実験手順

A mixture of ethyl 3-(4-chloro-phenyl)-3-oxo-propionate (5.8 g, 26.0 mmol) and 2H-pyrazol-3-ylamine (2.1 g, 26.0 mmol) was stirred at 150° C. for 2 h. EtOAc (22 mL) was successively added to the cooled mixture and stirring was continued at 0° C. for 0.5 h. The crystals were isolated by filtration to give 5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidine-7-ol (4.80 g, 75%) as a white solid. MS (ISP) 246.1 [(M+H)+]; mp 306-308° C.

後処理

  1. stirringstirring
  2. waitwas continued at 0° C. for 0.5 h
  3. customThe crystals were isolated by filtration

出典と根拠

ORDレコード
ord-6d89c031113b492a92ca149e956068c3
出典データセット
uspto-grants-2008_11
特許番号
US07446113B2

関連ノート

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