Pyrazol-3-ylamine → 5-(3,4-Dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

HRID 268996

反応式

HRID 268996 の反応式
[N:1]1[NH:2][C:3]([NH2:6])=[CH:4][CH:5]=1.[Cl:7][C:8]1[CH:9]=[C:10]([C:15](=O)[CH2:16][C:17](=O)[C:18]([F:21])([F:20])[F:19])[CH:11]=[CH:12][C:13]=1[Cl:14]>C(O)(=O)C>[Cl:7][C:8]1[CH:9]=[C:10]([C:15]2[CH:16]=[C:17]([C:18]([F:21])([F:19])[F:20])[N:2]3[N:1]=[CH:5][CH:4]=[C:3]3[N:6]=2)[CH:11]=[CH:12][C:13]=1[Cl:14]

参加物

4

反応物 2

HCID 74561Pyrazol-3-ylamineHCID 124462551-(3,4-Dichlorophenyl)-4,4,4-trifluorobutane-1,3-dione

生成物 1

HCID 170203565-(3,4-Dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
0 °C

実験手順

A mixture of 2H-pyrazol-3-ylamine (4.0 g, 48 mmol) and 1-(3,4-dichloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (11.4 g, 40 mmol) in acetic acid (80 mL) was heated at reflux for 4 h. The solution was poured into ice-cold 10% aqueous ammonia and the mixture was stirred at 0° C. for 0.5 h. The solid was isolated by filtration, triturated with EtOH (40 mL), and dried to give 5-(3,4-dichloro -phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine as a pale-yellow solid. MS (ISP) 332.1[(M+H)+]; mp 130-131° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 4 h
  3. customThe solid was isolated by filtration
  4. customtriturated with EtOH (40 mL)
  5. customdried

出典と根拠

ORDレコード
ord-5b96f0156eb24f0e874e412e4bffae29
出典データセット
uspto-grants-2008_11
特許番号
US07446113B2

関連ノート

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