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Hydrogen iodide → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen iodide | HCID 24841 | — |
| 反応物 | Sodium Bisulfite | HCID 23665763 | — |
| 反応物 | 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester | HCID 53834251 | — |
| 反応物 | 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid | HCID 54010068 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid | HCID 21322540 | — |
反応手順
1 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester, or the corresponding free hydroxy acid or 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid, is heated with 2 ml. of 67% hydriodic acid and 4 ml. of acetic acid at 150° for 1 hour and the mixture is poured onto ice and decolorized with NaHSO3 solution. After the customary work up, 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°, is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04151302 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-33adb9ea9eaf4650a352ffb45849f2e3 |
| 出典メモ | uspto-grants-1979_04 |