Phosphoric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])=[CH:11][CH:10]=1)(O)[CH3:7])[CH3:2].[I-].[K+].P(=O)(O)(O)O>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])=[CH:11][CH:10]=1)[CH3:7])[CH3:2]参加物
4
実験手順
A mixture of 32 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester, 8.7 g. of potassium iodide, 5.2 g. of red phosphorus and 45 ml. of 85% phosphoric acid is stirred and heated to 130° for 7 hours. It is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid ethyl ester.
後処理
- additionA mixture of 32 g
- temperature