5-Bromonicotinamide → HCID 11852032、化合物

HRID 269099

反応式

HRID 269099 の反応式
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:9]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)=[N:8][C:7]=12)#[CH:2].Br[C:27]1[CH:28]=[N:29][CH:30]=[C:31]([CH:35]=1)[C:32]([NH2:34])=[O:33]>>[F:15][C:12]([F:14])([F:13])[C:11]1[N:6]2[N:5]=[CH:4][C:3]([C:1]#[C:2][C:27]3[CH:28]=[N:29][CH:30]=[C:31]([CH:35]=3)[C:32]([NH2:34])=[O:33])=[C:7]2[N:8]=[C:9]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[CH:10]=1

参加物

3

反応物 2

HCID 18085-BromonicotinamideHCID 715397323-Ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

生成物 1

HCID 11852032HCID 11852032、化合物

実験手順

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.1) (400 mg, 1.13 mmol) and 5-bromonicotinamide [CAS 28733-43-9; commercially available] (204 mg, 1.0 mmol) according to general procedure II. Obtained as a yellow solid (140 mg, 26%). MS (ISP) 476.2 [(M+H)+]; mp 285-287° C.

出典と根拠

ORDレコード
ord-cf889c1e28514272a727a5540985fd20
出典データセット
uspto-grants-2008_11
特許番号
US07446113B2

関連ノート

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