Hydrochloric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid
反応式
C([O:3][C:4](=[O:22])[CH2:5][CH:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])=[CH:10][CH:9]=1)[CH3:7])C.Cl>C(O)(=O)C>[F:21][C:15]1[CH:16]=[C:17]([F:20])[CH:18]=[CH:19][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]([CH:6]([CH3:7])[CH2:5][C:4]([OH:22])=[O:3])=[CH:9][CH:10]=1参加物
4
実験手順
3.04 g. of 3-(2',4'-difluoro-4-biphenylyl)butyric acid ethyl ester is a mixture of 25 ml. of acetic acid and 25 ml. of 25% hydrochloric acid are heated under reflux for 90 minutes. The customary work up gives 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.
後処理
- additiona mixture of 25 ml
- temperatureunder reflux for 90 minutes
出典と根拠
- ORDレコード
- ord-51cd0608af284a479d91af5a28b7f132
- 出典データセット
- uspto-grants-1979_04
- 特許番号
- US04151302
反応ノート
読み込み中…