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HRID 269198作成日：2026年10月26日

2-Pyridinamine, 5-bromo-6-methyl- → 6-Methyl-5-[7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridin-2-ylamine

https://huagongshe.com/reaction/269198

反応式

関与物質

役割名称HCID仕込み量
反応物2-Pyridinamine, 5-bromo-6-methyl-HCID 170678—
反応物3-Ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidineHCID 71539732—
生成物6-Methyl-5-[7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridin-2-ylamineHCID 86608069—

反応手順

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.1) (355 mg, 1.0 mmol) and commercially available 6-amino-3-bromo-2-methylpyridine (168 mg, 1.0 mmol) according to general procedure II. Obtained as a dark-red solid (90 mg, 19%). MS (ISP) 462.2 [(M+H)+]; mp 251-254° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07446113B2
出典データセットuspto-grants-2008_11
ORD IDord-fd1830a865714a9c91e0fd1a665bc9cd
出典メモuspto-grants-2008_11