化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol | HCID 21322562 | — |
| 触媒 | Silver Nitrate | HCID 24470 | — |
| 触媒 | Silver(II) oxide | HCID 92152 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid | HCID 21322583 | — |
反応手順
Silver oxide, freshly prepared from 3.2 g. of AgNO3 and 0.8 g. of NaOH in 25 ml. of water, is added to a mixture of 2.78 g. of 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol and 2 g. of NaOH in 20 ml. of water. The mixture is heated under reflux for 2 hours and filtered. The filtrate is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid, m.p. 121°-123°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04151302 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-c1d12b4e009b4caea87982793f81e86f |
| 出典メモ | uspto-grants-1979_04 |