5-Bromo-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-2-thiophenesulfonamide → HCID 86608115、化合物

HRID 269328ノート

反応式

HRID 269328 の反応式
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=3)=[N:8][C:7]=12)#[CH:2].[OH:26][CH2:27][CH:28]([NH:31][S:32]([C:35]1[S:36][C:37](Br)=[CH:38][CH:39]=1)(=[O:34])=[O:33])[CH2:29][OH:30]>>[OH:26][CH2:27][CH:28]([NH:31][S:32]([C:35]1[S:36][C:37]([C:2]#[C:1][C:3]2[CH:4]=[N:5][N:6]3[C:11]([C:12]([F:14])([F:13])[F:15])=[CH:10][C:9]([C:16]4[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=4)=[N:8][C:7]=23)=[CH:38][CH:39]=1)(=[O:34])=[O:33])[CH2:29][OH:30]

参加物

3

反応物 2

HCID 653146455-Bromo-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-2-thiophenesulfonamideHCID 866080553-Ethynyl-7-trifluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

生成物 1

HCID 86608115HCID 86608115、化合物

実験手順

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.10) (178 mg, 0.5 mmol) and 5-bromo-thiophene-2-sulfonic acid (2-hydroxy-1-hydroxymethyl-ethyl)-amide (example B.54) (158 mg, 0.5 mmol) according to general procedure II. Obtained as an orange solid (117 mg, 40%). MS (ISN) 589.3 [(M−H)−]; mp 210° C.

出典と根拠

ORDレコード
ord-6effeb9ec73c45b1acc1bb747def49fa
出典データセット
uspto-grants-2008_11
特許番号
US07446113B2

反応ノート

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