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Hydrochloric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Tetraethyl orthocarbonate | HCID 66213 | — |
| 反応物 | 4'-(1-Bromopropan-2-yl)-2,4-difluoro-1,1'-biphenyl | HCID 53691440 | — |
| 反応物 | HCID 178455852 | HCID 178455852 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid | HCID 21322540 | — |
反応手順
2 g. of orthocarbonic acid tetraethyl ester are added to a solution of 2-(2',4'-difluoro-4-biphenylyl)-1-propylmagnesium bromide, prepared from 3.11 g. of 4-(1-bromo-2-propyl)-2',4'-difluorobiphenyl, in 40 ml. of THF and the mixture is stirred for 4 hours at 25°. Excess dilute hydrochloric acid is added slowly. The mixture is heated under reflux for 24 hours, allowed to cool and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04151302 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-ef8912ff8fa343f4841630136022f423 |
| 出典メモ | uspto-grants-1979_04 |