反応式
C1(C)C=CC(S(O)(=O)=O)=CC=1.N1C=CC=CC=1.[C:18]1([C:24]#[C:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][O:31]C2CCCCO2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CO>[C:18]1([C:24]#[C:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][OH:31])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1参加物
4
反応条件
- 温度
- 55 °C
実験手順
Pyridine toluene-4-sulphonate (0.75 g, 3 mmol) was added to a magnetically stirred solution of 2-(7-phenylhept-6-ynyloxy)-tetrahydro-2H-pyrane (7) (13.62 g, 50 mmol) in dry methanol (300 mL). The reaction mixture was stirred at 55° C. and monitored by TLC. When all the base material had been converted, methanol was distilled out on a rotary evaporator and water (200 mL) was added to the residue. The aqueous phase was extracted with petroleum ether (boiling point 40-60° C.)/Et2O 1:1 (5×50 mL). The combined organic phases were washed with water (2×20 mL) and dried (MgSO4). Distillation on a rotary evaporator yielded 9.1 g (97%) of a yellow viscous oil. TLC and NMR indicated a pure product.
後処理
- distillationmethanol was distilled out on a rotary evaporator and water (200 mL)
- additionwas added to the residue
- extractionThe aqueous phase was extracted with petroleum ether (boiling point 40-60° C.)/Et2O 1:1 (5×50 mL)
- washThe combined organic phases were washed with water (2×20 mL)
- dry with materialdried (MgSO4)
- distillationDistillation
- customon a rotary evaporator
出典と根拠
- ORDレコード
- ord-2facfffb0e2d44a9892ae3ed367c9f35
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07446226B2
関連ノート
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