Acetyl chloride → HCID 68947033、化合物

HRID 269439ノート

反応式

HRID 269439 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)(=[O:7])[CH3:6].[CH2:9]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>ClCCl>[C:5]([CH:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:11][CH2:10][CH2:9][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:7])[CH3:6]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 16476PentadecylbenzeneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 68947033HCID 68947033、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

A 500-ml-three-necked round-bottomed flask, with an efficient cooling was charged with aluminium chloride (5.82 g, 43.67 mmol) and dichloromethane (100 ml). Acetyl chloride (3.42 g, 43.67 mmol) was added to the vigorously stirred reaction mixture over a period of 15 minutes. Pentadecyl benzene (10 g, 34.66 mmol) was added over a period of 30 minutes; the clear solution was stirred at 0° C. for 2 hours and allowed to warm to room temperature. The reaction mixture was poured in ice and extracted with dichloromethane (3×100 ml), the combined organic layers was washed with 1 N hydrochloric acid (2×30 ml) and water (3×50 ml), dried over sodium sulfate and the solvent was evaporated to obtain 4-acetyl pentadecyl benzene as a low melting faint yellow solid. The yield was 10 g (87% of theoretical).

後処理

  1. temperatureA 500-ml-three-necked round-bottomed flask, with an efficient cooling
  2. temperatureto warm to room temperature
  3. additionThe reaction mixture was poured in ice
  4. extractionextracted with dichloromethane (3×100 ml)
  5. washthe combined organic layers was washed with 1 N hydrochloric acid (2×30 ml) and water (3×50 ml)
  6. dry with materialdried over sodium sulfate
  7. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-abea354b382545379932525665d4a8a5
出典データセット
uspto-grants-2008_11
特許番号
US07446234B2

反応ノート

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